The world has become a lot less stable and predictable and what worked in the past may not work anymore and what is immutable today could be replaced tomorrow with something entirely unfamiliar. The greatest leadership challenge in this world of unfathomable flux and friction is to constantly adjust to the shape-shifting technologies, competition, policies, regulations, moral-political fashions, and geopolitical arrangements. The new conditions require the leaders to navigate unending minefields of choices and compulsions. Today, leaders must get out of the rut of orthodox perceptions, assumptions, and approaches and free themselves from the entrenched leadership dogmas and practices. The leaders must unshackle themselves from the tyranny of instant gratification of the most powerful stakeholders and stake their leadership on ensuring the enterprise's relevance in the emerging economic, social, environmental and geopolitical context. In absence of absolute clarity and stability of technology, policy, supply chains, market access, demand and values, the leaders must find ways to build personal and organizational capacity for greater flexibility, agility and adaptability.